Time to treatment response in first episode schizophrenia: should acute treatment trials last several months?

Juan Gallego, Delbert Robinson, Serge Sevy, Barbara Napolitano, Joanne McCormack, Martin Lesser, and John Kane

Many first episode patients respond between weeks 8 and 16 of treatment with a single antipsychotic medication. Limited early symptom improvement does not identify with enough accuracy to be clinically useful those first episode patients who will not improve with a full 16 week trial.

Newer, second generation antipsychotics, including some LAIs, are an important and valuable treatment option for patients with first-episode or recent onset schizophrenia.