DSM Diagnosis of the First Psychosis Episode: Past, Present, and Future

Rajiv Tandon, MD, Dost Ongur, MD, and Matcheri Keshavan, MD

In this webinar, we will review the historical evolution of psychiatric diagnosis with special reference to psychosis disorders, by examining the development of the DSM framework, highlighting key conceptual shifts, strengths, and enduring limitations in classification, critically evaluate the current state of psychosis nosology, including major challenges such as heterogeneity, limited biological validity, and gaps in clinical utility, while discussing an integrative framework for today’s clinicians to use, and Envision future directions for psychiatric classification, focusing on the integration of biomarkers, dimensional approaches, and hybrid categorical–dimensional models to advance precision psychiatry and improve patient outcomes .